Vexpinem 500 Drug Interactions

General seizures have been reported in patients who received ganciclovir and imipenem/cilastatin. These drugs should not be used concomitantly unless the potential benefit outweighs the risk. Also, the prodrug valganciclovir can provoke seizures in combination with imipenem/cilastatin.
Concomitant probenecid has been shown to double the plasma level and half-life of cilastatin, but with no effect on its urinary recovery. Concomitant probenecid showed only minimal increases in plasma level and half-life of imipenem, with urinary recovery of active imipenem decreased to approximately 60% of the administered dose.
After co-administration with carbapenem agents, decreased plasma concentrations of valproic acid have been observed. The lowered valproic acid concentration can lead to inadequate seizure control. Alternative antibacterial agents should be considered. If imipenem and valproic acid are concomitantly administered, serum valproic acid concentrations should be closely monitored.
Imipenem/Cilastatin may cause positive Coombs test results.